16/04/2019
The Human Resources Strategy for Researchers

H/F : PhD researcher in electrophysiology – fonding ERC


  • ORGANISATION/COMPANY
    CNRS
  • RESEARCH FIELD
    Biological sciencesBiological engineering
    ChemistryBiochemistry
    PhysicsBiophysics
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    06/05/2019 23:59 - Europe/Brussels
  • LOCATION
    France › PARIS 15
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    35
  • OFFER STARTING DATE
    01/10/2019
  • EU RESEARCH FRAMEWORK PROGRAMME
    H2020 / ERC

The work will be performed in the “Channel-receptors” team, under the supervision of Pierre-Jean Corringer. The team belong to the CNRS unit “genes synapses and cognition and to the neuroscience department of the Institut Pasteur. The Institut Pasteur of Paris is internationally recognized and offers a highly dynamic social and scientific environment in the heart of Paris. Our lab studies the structure and function of pentameric ligand-gated ion channels, with a particular emphasis on understanding the structural bases of ion channel gating and regulation by small molecules. All projects in the lab are interdisciplinary in nature and combine structural techniques with functional approaches, including biochemistry, crystallography, pharmacology and electrophysiology, for which the lab is fully equipped. For more information on the Channel Receptor group, see (https://research.pasteur.fr/en/team/channel-receptors/)

Missions
PhD position on “Investigation of pentameric ligand-gated ion channels by Voltage-Clamp fluorometry”. The channel-receptor group of the Institut Pasteur in Paris downtown is seeking highly motivated candidates for a PhD position in electrophysiology to perform structure-function analysis in real time.
The successful candidate will be recruited for 36 months funded by an ERC postdoctoral fellowship.
Activities
The proposed position concerns voltage-clamp fluorometry, to monitor the ion channel gating by electrophysiology concomitant with protein motions by fluorescence in physiological conditions. The project aims at developing innovative fluorescent labeling techniques, involving news dyes or unnatural amino acid, to develop original conformational sensors. It will also involve molecular biology, protein biochemistry and kinetic modeling.
Skills
Applicants are expected to have a master in biology, biophysics, biochemistry or pharmacology. Previous experience in electrophysiology or voltage-clamp fluorometry, as well as molecular biology or other fluorescence techniques will be a clear asset.

Required Research Experiences

  • RESEARCH FIELD
    ChemistryBiochemistry
  • YEARS OF RESEARCH EXPERIENCE
    None
  • RESEARCH FIELD
    PhysicsBiophysics
  • YEARS OF RESEARCH EXPERIENCE
    None
  • RESEARCH FIELD
    Biological sciencesBiological engineering
  • YEARS OF RESEARCH EXPERIENCE
    None

Offer Requirements

  • REQUIRED EDUCATION LEVEL
    Chemistry: Master Degree or equivalent
    Physics: Master Degree or equivalent
    Biological sciences: Master Degree or equivalent
  • REQUIRED LANGUAGES
    FRENCH: Basic

Map Information

Job Work Location Personal Assistance locations
Work location(s)
1 position(s) available at
Gènes, synapses et cognition
France
PARIS 15

EURAXESS offer ID: 400011
Posting organisation offer ID: 9199

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