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    Institut Imagine
    Biological sciencesBiology
    First Stage Researcher (R1)
    30/09/2019 23:00 - Europe/Brussels
    France › Paris

Genetic Diseases Imagine Institute aim is to characterize and treat genetic diseases.

An ANR-funded 3 year post-doctoral position is available from December 2019 in the research group of Dr Sven Kracker, which is part of the human lymphohematopoiesis laboratory headed by Isabelle André at the Imagine institute in Paris.

The research team is especially interested in studying the molecular, genetic and pathophysiological mechanisms leading to primary antibody deficiencies (PADs). The overall objective of the work is to identify and characterize novel molecular causes for PADs and to investigate the impact of “hyper-activated” PI3K signalling on gene expression, lymphocyte function and differentiation.

The Imagine institute represents an excellent setting to pursue such studies.

We are looking for a talented and highly motivated postdoctoral researcher (m/f) with strong expertise in immunology and intracellular signaling, excited by clinical translational challenges and proven ability to work independently.

Main missions:

  • Implementation of the project in connection with the research lab and other clincial departments
  • Performing of functional studies in cellullar systems
  • Implementation, adaptation and coordination of cellular and molecular biology techniques
  • Apply for grant calls, results communication inside and outside the laboratory (European network, national and international conferences)

Required skills:

  • Mastery of flow cytometry
  • Mastery of in vitro cell culture techniques in confined spaces (SPF2) and excellent knowledge of molecular biology tools
  • Knowledge in genetic, epigenetic and RNA expression profiling analysis (whole exome sequencing, whole genome sequencing, RNA-Sequencing)
  • Expertise in immunology, cell signalling, genetic
  • Skills in use of computer tools (Word, Excel, Powerpoint, FlowJo or other flow cytometry analysis softwares, Prism, statistics tools)
  • Communicate, transmit knowledge and present data
  • Very good level of English (written, spoken, read)

Required qualifications:  

  • Rigor, methodology and organization, dynamism, autonomy and critical sense
  • Adaptability to time constraints, good laboratory practice
  • Interest in innovation, technology development and translational research
  • Motivation, interpersonal skills, initiative

Diploma and professional experience required:

  • Doctoral degree in life sciences, preferably in Immunology
  • Similar professional experience desired

Type of contract and amount of annual salary:

  • Fixed term contract for 12 months from December 1st 2019 (renewable up to 2 years)
  • Salary according to experience
  • Deadline for applications: September 30th, 2019

Applications in English including a cover letter, a detailed CV with publication list and references should be sent to Sarah ENOUZ at sarah.enouz@institutimagine.org


Selected publications on the subject:

Bouafia A, et al. (2019) Loss of ARHGEF1 causes a human primary antibody deficiency. The Journal of clinical investigation.

Deau MC, et al. (2014) A human immunodeficiency caused by mutations in the PIK3R1 gene. The Journal of clinical investigation.

Heurtier L, et al. (2017) Mutations in the adaptor-binding domain and associated linker region of p110delta cause Activated PI3K-delta Syndrome 1 (APDS1). Haematologica.

Coulter TI, et al. (2016) Clinical spectrum and features of activated phosphoinositide 3-kinase delta syndrome: A large patient cohort study. The Journal of allergy and clinical immunology.

Elkaim E, et al. (2016) Clinical and immunologic phenotype associated with activated phosphoinositide 3-kinase delta syndrome 2: A cohort study. The Journal of allergy and clinical immunology.

Work location(s)
1 position(s) available at
Imagine Institute INSERM

EURAXESS offer ID: 439839


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