- JOB
- Germany
Job Information
- Organisation/Company
- HBIGS Heidelberg Biosciences International Graduate School
- Research Field
- Biological sciences » Biology
- Researcher Profile
- First Stage Researcher (R1)
- Positions
- PhD Positions
- Application Deadline
- Country
- Germany
- Type of Contract
- Temporary
- Job Status
- Full-time
- Hours Per Week
- 40
- Offer Starting Date
- Is the job funded through the EU Research Framework Programme?
- Not funded by a EU programme
- Is the Job related to staff position within a Research Infrastructure?
- No
Offer Description
The PhD project is part of the Collaborative Research Center SFB 1324, which is a highly collaborative network of labs investigating the mechanisms of Wnt signaling in animal development and disease. Wnt signaling controls tissue patterning, stem cell homeostasis, proliferation and differentiation and is frequently dysregulated in human cancer.
In this project you will develop and apply advanced CRISPR genome engineering methods to investigate Wnt signaling in different model systems, including Drosophila, Hydra and cultured cells. Technology development will be in the areas of precise and efficient gene tagging, pooled in vitro and in vivo screens for functional genomics and precision CRISPR technology, such as prime- and base editing, for structure-function analysis. Transferability of methods across experimental systems will be an important aspect of this work. Overall, the project aims to harness targeted genome modifications to shed light on how Wnt proteins are produced and distributed in animal tissues and how receiving cells transduce these signals into biological responses.
Where to apply
Requirements
- Research Field
- Biological sciences » Biology
- Education Level
- Master Degree or equivalent
Skills/Qualifications
We are looking for a candidate who
• holds a masters’ degree in biology, life sciences or a related field
• has an excellent background in molecular biology, developmental and cell biology, or biochemistry
• experience in genome engineering approaches is of advantage
• shows strong laboratory, analytical and communication skills
• is enthusiastic, motivated, result-driven, and shows initiative
• has good organization, writing and communication skills
• is able to work independently, but also collaboratively and across different teams
• an excellent written and oral command of English is essential
- Languages
- ENGLISH
- Level
- Excellent
Additional Information
Benefits
This project will be part of the SFB 1324 (Mechanisms of Wnt Signaling) of Heidelberg University, with participating labs at Karlsruhe Institute of Technology (KIT), University of Göttingen and University of Düsseldorf. The project will be based in Michael Boutros lab at Heidelberg University and DKFZ, with close links to the group of Motomu Tanaka (Physical Chemistry), Thomas Holstein (COS) and others.
Selection process
Please submit your application through the HBIGS application system:
https://www.hbigs.uni-heidelberg.de/en/your-application
Additional comments
Please visit our website for more information on the Collaborative Research Center (https://www.sfb1324.de).
Questions about the project can be directed to Dr. Fillip Port (f.port@dkfz.de).
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- German Cancer Research Center DKFZ
- Country
- Germany
- City
- Heidelberg
- Postal Code
- 69120
- Street
- Im Neuenheimer Feld 580
- Geofield
Contact
- City
- Heidelberg
- Website
- Street
- Im Neuenheimer Feld 501
- Postal Code
- 69120
- contact@hbigs.uni-heidelberg.de